18 Feb 2017
Despite my New Year’s Resolutions, my lupus has been more active lately. I’ve been feeling very fatigued (although it’s hard to determine how much is due to being a working mama and how much is due to lupus). I’ve also had mouth sores, pericarditis and joint pains. My blood tests confirmed my suspicions and when I saw my rheumatologist she changed my medications and took me off of work for a week to rest. In addition to the plaquenil (which I always take) and the imuran, she added N-Acetylcysteine, otherwise known as NAC.
When I was in residency I remember using this to treat acetaminophen (tylenol) overdoses and also giving it to patients to protect their kidneys from contrast dye given with CT scans (although I don’t know if this has proven to actually be protective).
There was a small study published in 2012 where lupus patients treated with NAC had decreased disease activity and decreased fatigue after 3 months of treatment with 2.4-4.8g per day (um, that means I’m taking 8 pills a day!). There’s a larger, longer trial underway right now. I’m personally about 3 weeks into my own personal trial. So far I haven’t felt that much different, but it looks like it takes a few months to start to see the difference. So, I’ll keep you posted, fingers crossed!